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 Table of Contents  
REVIEW ARTICLE
Year : 2019  |  Volume : 52  |  Issue : 4  |  Page : 111-121

Chronic neuropathic pain following inguinal hernia repair


Department of Surgery, Tahri Mohammed University, Bechar, Algeria

Date of Submission27-Jul-2017
Date of Decision07-Jun-2018
Date of Acceptance02-Apr-2019
Date of Web Publication27-Aug-2019

Correspondence Address:
Dr. Toufik Berri
BP 71 Maghnia 13300, Tlemcen
Algeria
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/fjs.fjs_125_17

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  Abstract 


Since recurrence rates have been considerably reduced with mesh repairs, chronic pain has recently become the main concern after inguinal hernia repair (IHR), with significant impact on patient satisfaction, societal cost, and quality of life. Some 31% of all patients with persistent postsurgical pain develop neuropathic pain (NP) after IHR seeing that the inguinal nerves that cross the surgical field can directly or indirectly be damaged. Because of the multiplicity of the risk factors and the complexity of the pathophysiological mechanisms, substantial attention has been devoted to the multidisciplinary approaches and to the preventive measures. More clinical trials are needed to improve the level of evidence of the use of pharmacological, surgical, and interventional procedures in both prevention and treatment of chronic NP following IHR. In this article, the current objectives are to review the incidence, risk factors, pathogenesis, diagnosis, prevention, and treatment of chronic NP after IHR.

Keywords: Chronic pain, groin, hernia repair, inguinal hernia, neuropathic pain


How to cite this article:
Berri T. Chronic neuropathic pain following inguinal hernia repair. Formos J Surg 2019;52:111-21

How to cite this URL:
Berri T. Chronic neuropathic pain following inguinal hernia repair. Formos J Surg [serial online] 2019 [cited 2019 Nov 19];52:111-21. Available from: http://www.e-fjs.org/text.asp?2019/52/4/111/265487




  Introduction Top


Chronic postsurgical pain is a pain that persists beyond normal healing time and lasts at least 3 months; other causes for the pain have to be excluded, in particular pain from a condition preceding the surgery.[1],[2] The etiology and mechanism of chronic pain after inguinal hernia repair (IHR) is complex and includes different types of pain: neuropathic, nonneuropathic, somatic, and visceral pain.[3] Neuropathic pain (NP) after IHR develops as a consequence of a lesion affecting the somatosensory system,[4] in particular after direct damage of the inguinal nerves.[5],[6] Alfieri et al. defined the chronic postherniorrhaphy pain as an NP arising in patients who did not have groin pain before the hernia operation, or if they did, the postoperative pain differs from the preoperative pain.[7]


  Incidence Top


The reported incidence of chronic pain following IHR varies widely because of the nonstandardization of follow-up period, the diversity of pain-assessment methods and pain descriptors, and multiplicity of surgical procedures (open vs. laparoscopic repair and mesh vs. nonmesh repair). In a relatively recent systematic literature review, the prevalence of NP was 31% among patients with persistent postsurgical pain after IHR.[8]


  Risk Factors Top


Risk factors, including patient-dependent or surgery-dependent factors, have been implicated in the development of chronic pain following IHR [Table 1]. However, in the postoperative persistent NP, particularly after IHR, predictors are not completely established, and some are only hypothesized since there is a significant lack in studies on this topic.
Table 1: Risk factors for chronic pain after inguinal hernia repair

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To identify potential predictors associated with the persistence of NP, a Delphi study was conducted among 17 experts in the field of NP. Twelve important predictors were retained; personal patient factors (depression, anxiety, pain coping, and pain catastrophizing), environmental factors (surgery as treatment for NP), functions and structure (allodynia, hyperalgesia, duration of the complaints, duration of continuing pain, and continued high pain), and participation and trait anxiety/depression as a part of health-related quality of life.[18] Otherwise, a systematic review of high-quality studies demonstrated that unlike female gender, older age was considered as a predictor for nonsurgical persistent NP.[19] Wilson et al. aimed to identify patient characteristics that are predictors for developing NP following breast surgery. African–American race, history of either diabetes mellitus or fibromyalgia, and treatment with chemotherapy was all associated with an increased risk of postoperative NP.[20] Whereas, in patients who underwent surgery for sarcoma of the extremities or pelvis, multiple surgeries was identified as independent predictor of postoperative NP.[21]

Nerve injury is the most important recognized risk factor in postoperative NP. In addition to the fact that the three nerves running in the inguinal canal are highly exposed to injury during groin hernia surgery, a well-documented relationship exists between nerve damage and development of a persistent NP after IHR.[9] Furthermore, open hernia repair techniques are considered as a serious factor since minimally invasive surgery contributed extremely in reducing postoperative pain incidence.[9],[10],[22]

Factors other than direct nerve injury are an important cause of nerve lesion and chronic NP. Although the use of meshes is considered to be the gold standard in IHR, patients continue to complain about persistent NP. In fact, contact between the mesh and nerves may induce nerve irritation because of the mesh-related inflammatory reaction and fibrosis. Furthermore, unlike within the inguinal canal, nerves in the preperitoneal space are more predisposed to the mesh-related irritation because there is no investing fascia to protect them from direct contact with the mesh.[23] After mesh implantation, the pain might be caused by the weight and composition of the material itself. Results of numerous studies on the impact of the mesh on the postsurgical pain were in favor of light meshes compared with heavy meshes.[15],[16] Moreover, mesh fixation with sutures or staples has been implicated as an important cause of chronic inguinal pain (nerve entrapment). Low degree of specialization and lack of experience of the surgeon may contribute in the occurrence of postsurgical NP.[24]

The most important postoperative factor is the presence and severity of acute postoperative pain,[5],[9],[25] so moderate-to-severe early postoperative pain plays a major role for developing persistent pain. In 10%–50% of patients who undergo common operations, acute postoperative pain may progress to persistent pain.[5] A multi-center, prospective study conducted on 593 patients suggested that early acute postsurgical NP significantly increases the risk of persistent postsurgical NP.[26]


  Pathogenesis Top


Nerve injuries

When performing IHR, the ilioinguinal nerve, the iliohypogastric nerve, and the genital branche of the genitofemoral nerve crossing the operative field can be stretched, entrapped, crushed, burned, or sectioned. The mostly encountered lesions are compression caused by sutures, staples, or mesh-related fibrosis or meshoma,[23] and transection of the predisposed nerves.

The entrapped segment of the nerve may suffer from venous stasis, intra, and perineural edema, ischemia, and eventually fibrosis and scar tissue formation.[27] In addition, peripheral nerve injuries may lead to the formation of two types of neuromas: neuroma in continuity which usually involves all degrees of nerve injury, from normal to neurotmesis, and end-bulb neuroma which occurs anywhere a nerve is completely divided and is unopposed by another neural tissue.[28] On the other hand, when peripheral nerve tissue comes in contact with polypropylene mesh, continuous inflammatory response, axonal dilatation, myelin degeneration, endoneurial edema with thickening of both the endoneurium and perineurium, separation of myelin layers, and fibrosis result and can lead to peripheral neuropathy.[29]

Depending on the type, the site, and severity of the lesion [Table 2], the injured nerve may regenerate with possible functional recovery. Thus, neuropraxia normally full recovers in days or weeks by remyelination, while injuries of more severe grades may regenerate during months by collateral axon sprouting from the proximal axonal end to its distal target.
Table 2: Seddon and Sunderland classification of nerve injury

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Mechanisms

The development of chronic NP after IHR involves different levels in the nociceptive system which comprises primary afferent pathways (Aδ, Aβ, and C fibers), second-order neurons in the dorsal horn of the spinal cord with a projection to the brain, and descending inhibitory pathways (antinociceptive system).

Peripheral sensitization

Surgical handling induces the release of molecules and inflammatory mediators such as prostaglandin, interleukins, tumor necrosis factor alpha, growth factors, neuropeptids, substancePand histamine in the injured area from nociceptors or nonneural cells (mast cells, basophils, platelets, macrophages, neutrophils, endothelial cells, keratinocytes, and fibroblasts).[30] Inflammatory actions alter the properties of peripheral terminals of high-threshold nociceptor sensory nerves by giving rise to the phosphorylation of ion channels and receptors on the nociceptor terminal membrane, reducing threshold and increasing excitability of the peripheral injured afferent nerve fibers [Figure 1]a. As a result, normally nonpainful stimuli can cause pain. This transient mechanism of acute pain is known as peripheral sensitization and disappears after regression of the inflammation and healing.[31]
Figure 1: Mechanisms of chronic neuropathic pain. (a) Peripheral sensitization, (b) central sensitization

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Central sensitization

In some cases, when the pain persists beyond the acute phase, another important mechanism called central sensitization take place [Figure 1]b. In fact, increased nociceptive input from the periphery into the central nerve system leads to and sustains central sensitization which is a form of synaptic plasticity in the spinal cord that amplifies pain signaling. In addition, a change in the descending antinociceptive system takes part in the development of central sensitization. This kind of neuroplasticity is experienced as abnormal hyperexcitability to a normal sensory stimulus experienced in the area of injured nerves and neighboring uninjured nerves.[32],[33] Three main mechanisms are implicated in central sensitization: alteration in glutamatergic neurotransmission/N-methyl-d-aspartate receptor-mediated hypersensitivity, loss of tonic inhibitory controls, and glial-neuronal interactions.[31] Furthermore, multiple studies highlighted also the role of microRNAs in molecular mechanisms of the transition from acute physiological pain to pathological persistence.[30]


  Diagnosis Top


Assessment of chronic neuropathic pain after inguinal hernia repair

Clinical assessment

The identification of NP is based on subjective signs and induced symptoms by tactile, thermal, and painful stimulus. Although there are no specific pain descriptors for NP, tingling, burning, and shooting are the most typical signs of pain expression.[34] Allodynia (pain due to a normally innocuous stimulus) and hyperalgesia (increased pain from a stimulus that usually provokes pain) are important objective symptoms of NP.[32] Evenly, hypoesthesia (abnormally reduced sensation of a tactile stimulus), hypoalgesia (abnormally reduced pain sensation to a noxious stimulus), and numbness (absence of sensation) should be assessed. Frequently, both positive and negative signs are present in the same affected area; hence, the examiner may meticulously search hypoesthesia or even areas of anesthesia within painful sites which might mask the presence of a potential sensory loss area. However, sensory loss area might preclude the recognition of positive signs.[32] This phenomenon permits to distinguish NP from nociceptive pain.[33]

Physical evaluation of NP should use touch, pinprick, pressure, cold, heat, vibration, and temporal summation to map out areas of abnormal somatosensory functions. Symptoms should be sought in proximity to the inguinal scar and in the supplied territories by the three inguinal nerves (scrotum, labium, and/or upper inner thigh) keeping in mind the difficulty to identify precisely the nerve involved in causing the pain because of the anatomical varieties and connections between the nerves. In addition, clinical neurological examination of the affected area should be carefully conducted with comparison with contralateral or other unaffected body regions. Moreover, upper body stretching or twisting and/or hip joint flexing may cause pain from nerve traction or compression.[6]

Pain during sexual activity was reported in 22.1% of patients after inguinal herniorrhaphy (12.3% of genital or ejaculatory pain).[35] In a recent study, the rate of ejaculatory pain was found to be 2.2%.[36] Testicular pain that may be caused by nerve damage or testicular ischemia was encountered in 1%–6% of patients.[11] Earlier, the cremaster reflex was reported to be absent after division of the genital branch of the genitofemoral nerve.[37]

Neuropathic pain assessment tools

Numerous methods are available for screening and assessing chronic pain and discriminating between neuropathic and nonNP. For evaluating the different symptoms of NP, scales and questionnaires are developed to measure the various dimensions of pain experiences, particularly for large cohorts of patients in clinical studies [Table 3].[34] Quantitative sensory testing, a widely used tool in chronic pain assessment, uses a battery of mechanical (tactile, vibration, blunt pressure, and pinprick) and thermal (cold, heat, cold pain, and heat pain) stimuli applied to the affected area to assess disturbances in sensation that are quantified on a rating scale.[38] Thus, it allows delineating the types of nerve fibers involved, determining the threshold of detection of stimuli, diagnosing and assessing the severity of nerve damage, and helping to quantify treatment effects on NP symptoms. Laser evoked potentials have been adopted in demonstrating small-fiber involvement in numerous peripheral nervous system disorders. Recently, it is used for the investigation of the pathophysiological mechanisms of pain and the diagnosis of NP. Similarly, contact heat evoked potentials may be an objective, noninvasive diagnostic tool in small-fiber neuropathy.[39] Unfortunately, data concerning the usage of these tools in chronic NP assessment after IHR are limited. In addition, nerve conductance study is also an important tool in establishing a diagnosis of peripheral nerve lesion, but it is not easy to apply this technique on inguinal nerves because of the small caliber of the nerve fibers. Ultrasound, computed tomography scan, and MRI allow ruling out a recurrence or mesh-related factors in relation with chronic postoperative pain. Magnetic resonance neurography is effective and accurate in the clinical evaluation of peripheral nerve injury, but it is radiologist dependent and still rarely used in postherniotomy chronic pain assessment. In another technique aiming to identify which of these nerves, ilioinguinal, iliohypogastric, or genitofemoral nerve are involved, peripheral nerve block or paravertebral root block with a local anesthetic may be practiced as a diagnostic tool to determine the origin of NP.[3]
Table 3: Neuropathic pain assessment tools

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Measurement of quality of life after inguinal hernia repair

Although the patient's health-related quality of life after surgeries can be assessed using scales and questionnaires, more standardization is needed following IHR [Table 4]. Visual analog scale is the most commonly used assessment tool for pain measurement and is widely utilized in questionnaires. Persistent pain following IHR can also be assessed using a linear analog pain score (0–100; no pain = 0; mild pain <10; moderate pain 10–50; and severe pain >50).[40]
Table 4: Questionnaires for the measurement of health-related quality of life

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  Prevention Top


Prevention of persistent NP after IHR is still a challenge because of the heterogeneity of mechanisms and the multiplicity of risk factors. [Figure 2] summarizes the key points to reduce the risk of occurrence of this complication.
Figure 2: Prevention of chronic neuropathic pain after IHR. ASIS: anterior superior iliac spine, IHR: Inguinal hernia repair

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Nerve handling

Since nerve trauma is the main factor of the pain, a perfect knowledge of the neuroanatomy of the groin and an increased awareness in dissection may minimize intraoperative nerve injury. During open IHR, identification and protection of the three nerves may prevent chronic NP,[10],[41] while if <3 nerves are identified, more postoperative pain is present. However, a more recent prospective study found no difference in the risk of developing functional pain-related impairment in patients with and without intraoperative nerve identification.[42] To reduce the risk of nerve damage, care should be taken when incising the external oblique aponeurosis to prevent injury to the surfaced branches of the ilioinguinal or iliohypogastric nerves [Figure 3]. Usually sited in juxtaposition to the external spermatic vessels, the genital branch is protected by keeping the visible blue external spermatic vein with the spermatic cord, whereas it is being lifted from the inguinal floor.[43],[44] In addition, the cremaster should be saved and incised longitudinally rather than transversely to reduce the likelihood to damage the ilioinguinal and genital branch nerve. Surgeons should avoid constricting the external ring to protect the ilioinguinal nerve from compression and avoid traumatizing the intramuscular portion of the iliohypogastric nerve by avoiding suturing the lower edge of the internal oblique muscle.[45] During laparoscopic IHRs, placement of trocar sites 2 cm above a line drawn transversely between the right and left anterior superior iliac spines (ASISs) would avoid injuring ilioinguinal and iliohypogastric nerves.[46] Surgeons should avoid deep insertion of staples or tacks and tacking of the mesh lateral to the spermatic vessels in the so-called “triangle of pain” because of the risk of injury to the femoral branch of the genitofemoral nerve or the lateral cutaneous nerve of the thigh [Figure 4]. Furthermore, to avoid nerve trauma within the inguinal canal, staples or tacks should be placed outside these at risk areas: the ilioinguinal nerve is at risk lateral to the internal ring, the genital branch of the genitofemoral nerve is at risk medial to the internal ring, and the iliohypogastric nerve is at risk along its entire inguinal course.[47] Evenly keeping the nerves in their natural bed and preserving, the covering fascia may reduce the risk of chronic pain.[7],[45]
Figure 3: (a) Ilio-inguinal nerve (the spermatic cord is lifted out of the horizontal incision. Right side when performing ONSTEP procedure). (b) Ilio-hypogastric nerve (aponeurosis of the external oblique muscle is incised transversally and the caudal flap is lifted. Right side when performing ONSTEP procedure)

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Figure 4: Triangle of pain, an area bounded superiorly by the iliopubic tract and medially by the spermatic vessels (left side when performing TAPP procedure)

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A suspected injured nerve or a nerve which might interfere with the positioning of the mesh should be saved, divided, or resected? In such case, it is advisable to resect the nerve as proximally as possible or under tension so that it retracts into the muscle or behind the peritoneum.[7],[48] Current literature is inconsistent concerning the management of the cut ends of nerves. Hence, cut ends could be left without treatment, implanted in the muscle, crashed, ligated, cauterized, or soaked with phenol solution to prevent neuroma formation.[7]

Prophylactic neurectomy of the ilioinguinal nerve has no benefit in reducing chronic pain after open IHR and is not recommended.[22],[49] However, it may lead to an increased rate of groin numbness.[50] Pragmatic division of the genital branch of the genitofemoral nerve and iliohypogastric neurectomy seems beneficial.[48],[51]

Biomaterial of the mesh and mesh fixation

Meshes inducing less inflammatory reaction were designed, and light-weight meshes were compared to standard polypropylene meshes with encouraging results.[15],[16] Fixation techniques of meshes are also incriminated as a cause of pain; however, there is insufficient evidence to promote fibrin sealant, self-fixing meshes, or glues ahead of suture fixation.[52],[53] However, a recent meta-analysis of randomized control trials addressed in part this issue and found a lower incidence of early chronic pain in patients with biological glue fixation of the mesh in Lichtenstein IHR.[54] In laparoscopic surgery, in spite of tack or staple mesh fixation is the most widely applied technique, nonmechanical mesh fixation is considered as an alternative procedure with no real advantage in terms of chronic pain.[55],[56] Otherwise, studies comparing different tack materials for mesh fixation did not show any benefit from any type of fixation.[57]

Minimally invasive procedures

Minimally invasive procedures, derived from Stoppa, Rives, and Alexandre, with deep mesh implantation, are developed to lower the risk of developing chronic groin pain. Proponents of these procedures stake on the minimal dissection of the inguinal canal, the site of the mesh far from the inguinal nerves, and application of the mesh by the abdominal pressure without fixation. In the laparoscopic era, several studies have demonstrated a clear advantage of laparoscopic IHR over open repair in terms of reduced chronic postoperative pain.[58],[59],[60] However, unlike open techniques, very few researches have been interested in the type of pain after laparoscopy such as that of Bansal et al. in which most of the patients had non-NP character.[61] Transabdominal preperitoneal and the totally extraperitoneal approaches have similar chronic pain incidence.[58] When only considering chronic pain, endoscopic surgery is superior to open mesh for the repair of recurrent hernias.[10] In addition to the classical laparoscopic approaches, a recent study demonstrates that robotic-assisted IHR appears to be associated with low chronic pain and high health-related quality of life in the long term.[62]

Preventive analgesia

It was found in a meta-analysis that preventive analgesia was effective in reducing the incidence of chronic postsurgical NP.[63] This approach aims to block the transmission of the primary afferent injury discharge, decrease inputs into the dorsal horn and stop central sensitization. Provision of good analgesia to reduce acute postoperative pain may not completely prevent chronic pain but instead partially reduce its incidence, intensity, or duration.[64] Postoperative gabapentinoids or ketamine treatment, or infiltration of local anesthetic might prevent the development of severe chronic pain.[3] Although there is evidence that gabapentinoids may decrease the incidence of chronic pain, there effect in hernia surgery is uncertain.[63] Sen et al. reported that the gabapentin-treated patients reported less intense pain at 1, 3, and 6 months after inguinal herniorrhaphy in comparison with the placebo group.[65] However, a relatively recent randomized study showed that the administration of pregabalin has no effect on preventing the development of chronic pain following inguinal hernia surgery.[66] The concept of attenuating acute postoperative pain using preemptive pre- and intra-operative analgesia in order to reduce peripheral and central sensitization need more investigation and refinement.

Regional anesthesia

In a Cochrane systematic review and meta-analysis comparing regional anesthesia versus conventional analgesia for the prevention of persistent postoperative pain, it was found that epidural anesthesia and paravertebral block, respectively, may prevent postoperative pain after thoracotomy and breast cancer surgery in about one out of every four to five patients treated.[67] The rarity of studies evaluating the effect of regional anesthesia on chronic pain following IHR does not allow the development of appropriate treatment protocols.

Psychological treatments and educational programs

A few studies related to hernia surgery that examining these issues have been published. Considering psychological risk factors, when treating pain-related fear preoperatively, the transition of acute pain to chronicity may be controlled, and the pain severity may be reduced.[68]


  Treatment Top


Treatment of persistent NP after IHR is still a challenge because there is a lack of evidence-based treatment strategies. In this section, we focus on therapeutic modalities such as pharmacological, surgical, and interventional treatment that may procure sufficient pain relief [Figure 5].
Figure 5: Therapeutic modalities of chronic neuropathic pain after IHR. TAD: Tricyclic antidepressants, SNRI: Serotonin–norepinephrine reuptake inhibitors, Cα2-δL: Calcium channel α2-δ ligands, IHR: Inguinal hernia repair

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Pharmacological therapy

Various guidelines recommended certain drugs for treatment of NP such as tricyclic antidepressants, selective serotonin-norepinephrine reuptake inhibitors (e.g., duloxetine and venlafaxine), calcium channel α2-δ ligands (e.g., gabapentin and pregabalin), tramadol, strong opioids although their use in chronic NP is debatable, certain antidepressant medications (e.g., citalopram and paroxetine), certain antiepileptic medications (e.g., carbamazepine, lamotrigine, topiramate, and valproic acid), and lidocaine 5% and capsaicin patches. So far, the utility of pharmacological treatment in the management of chronic groin postoperative pain is unclear.

Surgical therapy

Surgical treatment should be considered when NP is refractory to analgesics for at least 1 year after the initial repair, pain intensity impedes activity, and postoperative pain is different from preoperative pain.[7],[69] Surgery, with both open and laparoscopic approaches, consists of resection of entrapped nerves (neurectomy), mesh removal in mesh-related pain, removal of endoscopic staples and tacks or fixating sutures, or excision of a neuroma.[10],[70],[71],[72] Neurolysis and simple division of the nerves without complete resection are not recommended.[7],[45]

Resection of ilioinguinal, iliohypogastric, and genital nerve was reported to be a proven surgical treatment for chronic postherniorrhaphy pain with 85% of complete resolution of pain.[23] Recently, neurectomy is the most recommended procedure and because of communications between nerves, all three nerves should be included.[7] Nerves resection is practiced through open, laparoscopic, or endoscopic approach.

Triple open neurectomy can be achieved through a two-stage operation including ilioinguinal and iliohypogastric neurectomies through an open inguinal approach and genital nerve neurectomy through a flank approach or through a one-stage procedure with resection of the three nerves within the inguinal canal.[73] As seen in preventive neurectomy, the dissected nerves should be resected as proximally and distally as possible.[45] For the iliohypogastric nerve, Amid resected the intramuscular portion of this nerve instead of cutting the nerve at the point of its emergence from the internal oblique muscle and pain relief was complete in >95%.[23] After open and laparoscopic preperitoneal mesh repair, inguinal triple neurectomy does not relieve pain due to the genitofemoral nerve irritation so an extension of the standard triple neurectomy to include the genitofemoral nerve overlying the psoas muscle was reported as a safe and effective procedure. The main trunk of the genitofemoral nerve is reached within the retroperitoneal space through an inguinal incision and a short segment of the nerve is resected.[47]

Laparoscopic retroperitoneal triple neurectomy may be performed through a transabdominal or extraperitoneal approach.[74],[75] In the absence of recurrence or meshoma, laparoscopic triple neurectomy of the ilioinguinal, iliohypogastric, and genitofemoral nerve trunks in the retroperitoneal lumbar plexus was reported to be more effective than standard triple neurectomy and open extended triple neurectomy.[75] This procedure is preferred to treat pain following open and laparoscopic preperitoneal mesh repair because nerves within the preperitoneal space are not easily accessible.[7] Laparoscopy has the advantage to avoid complications of reoperation, the possibility to disrupt the prior hernia repair, and the difficulty of identifying the three inguinal nerves in the reoperative inguinal canal.[75]

Resection of the paravasal nerves within the inguinal canal seems to be a useful addition to a triple neurectomy for patients with orchialgia associated with inguinodynia.[23] However, after open or laparoscopic preperitoneal mesh repair, orchialgia has no established surgical treatment because the lamina propria of the vas deferens is not easily accessible between the mesh and the seminal vesicle.[47]

In some cases when removal of the mesh is needful, it is not necessary to remove the material completely,[45] and associate neurectomy provides more effective treatment of persistent inguinodynia.[75] Furthermore, it seems logical that treatment of NP caused by staples, tacks or fixating sutures consists of removal of these devices, particularly since laparoscopic removal of offending tacks used for mesh fixation in the preperitoneal space has been successfully practiced.[76] However, removal of meshes, entrapping sutures, or fixating devices and leaving the injured nerves may not lead to NP relief.[7]

Nonsurgical interventional therapies

There is limited evidence for the use of local nerve blocks for the treatment of persistent pain following surgery of the groin. Very few studies attempted to evaluate ultrasound-guided techniques for selective block of the ilioinguinal and iliohypogastric nerves with controversial results,[77],[78] whereas for ultrasound-guided blockade of the genital branch of the genitofemoral nerve, several review articles has just described the technique. Neuroablative techniques including ultrasound-guided cryoablation which destructs selectively axons and myelin sheaths, and chemical neurolysis using phenol or alcohol have been used in the treatment of persistent postoperative pain.[79] Pulsed radiofrequency is an invasive pain treatment technique that uses electromagnetic energy applied at the vertebral level using fluoroscopically-guided localization of T12, L1, and L2 (dorsal root ganglia) or at the peripheral level (near the ASIS). Although this neuroablative technique provided efficacy in pain relief, its evidence base in the treatment of persistent pain after IHR is limited.[80],[81] Peripheral nerve stimulation, dorsal root ganglion stimulation, and spinal cord stimulation are neuromodulation techniques in which small implantable electrical devices provide pain relief by producing paresthesias in the corresponding areas of pain.[82],[83] Currently, this field remains poorly studied and further well-designed studies on neuromodulation for chronic pain relief after IHR should be conducted.


  Conclusion Top


Although tension-free procedures are considered as the gold standard of hernia repair, persistent postoperative pain continues to be reported after mesh implantations. Management of patients with chronic NP is a common and challenging problem after IHR. The complexity of mechanisms, wide variety of causes, and heterogeneity in clinical presentation require meticulous assessment and special investigations to recognize the NP, and multidisciplinary approach to produce effective treatment. More clinical trials are needed to identify patients who are at high risk and to develop preventive treatment strategies of chronic NP following hernia surgery.

Financial support and sponsorship

Nil.

Conflicts of interest

There are no conflicts of interest.



 
  References Top

1.
Treede RD, Rief W, Barke A, Aziz Q, Bennett MI, Benoliel R, et al. Aclassification of chronic pain for ICD-11. Pain 2015;156:1003-7.  Back to cited text no. 1
    
2.
Merskey H, Bogduk N, editors. Task Force on Taxonomy of the IASP. In: Classification of Chronic Pain: Descriptions of Chronic Pain Syndromes and Definitions of Pain Terms. 2nd ed. Seattle: IASP Press; 1994.  Back to cited text no. 2
    
3.
Bjurstrom MF, Nicol AL, Amid PK, Chen DC. Pain control following inguinal herniorrhaphy: Current perspectives. J Pain Res 2014;7:277-90.  Back to cited text no. 3
    
4.
Treede RD, Jensen TS, Campbell JN, Cruccu G, Dostrovsky JO, Griffin JW, et al. Neuropathic pain: Redefinition and a grading system for clinical and research purposes. Neurology 2008;70:1630-5.  Back to cited text no. 4
    
5.
Kehlet H, Jensen TS, Woolf CJ. Persistent postsurgical pain: Risk factors and prevention. Lancet 2006;367:1618-25.  Back to cited text no. 5
    
6.
Loos MJ, Roumen RM, Scheltinga MR. Classifying post-herniorrhaphy pain syndromes following elective inguinal hernia repair. World J Surg 2007;31:1760-5.  Back to cited text no. 6
    
7.
Alfieri S, Amid PK, Campanelli G, Izard G, Kehlet H, Wijsmuller AR, et al. International guidelines for prevention and management of post-operative chronic pain following inguinal hernia surgery. Hernia 2011;15:239-49.  Back to cited text no. 7
    
8.
Haroutiunian S, Nikolajsen L, Finnerup NB, Jensen TS. The neuropathic component in persistent postsurgical pain: A systematic literature review. Pain 2013;154:95-102.  Back to cited text no. 8
    
9.
Aasvang EK, Gmaehle E, Hansen JB, Gmaehle B, Forman JL, Schwarz J, et al. Predictive risk factors for persistent postherniotomy pain. Anesthesiology 2010;112:957-69.  Back to cited text no. 9
    
10.
Simons MP, Aufenacker T, Bay-Nielsen M, Bouillot JL, Campanelli G, Conze J, et al. European Hernia Society guidelines on the treatment of inguinal hernia in adult patients. Hernia 2009;13:343-403.  Back to cited text no. 10
    
11.
Aasvang E, Kehlet H. Chronic postoperative pain: The case of inguinal herniorrhaphy. Br J Anaesth 2005;95:69-76.  Back to cited text no. 11
    
12.
Reddi D, Curran N. Chronic pain after surgery: Pathophysiology, risk factors and prevention. Postgrad Med J 2014;90:222-7.  Back to cited text no. 12
    
13.
Dominguez CA, Kalliomäki M, Gunnarsson U, Moen A, Sandblom G, Kockum I, et al. The DQB1 * 03:02 HLA haplotype is associated with increased risk of chronic pain after inguinal hernia surgery and lumbar disc herniation. Pain 2013;154:427-33.  Back to cited text no. 13
    
14.
Belfer I, Dai F, Kehlet H, Finelli P, Qin L, Bittner R, et al. Association of functional variations in COMT and GCH1 genes with postherniotomy pain and related impairment. Pain 2015;156:273-9.  Back to cited text no. 14
    
15.
Uzzaman MM, Ratnasingham K, Ashraf N. Meta-analysis of randomized controlled trials comparing lightweight and heavyweight mesh for lichtenstein inguinal hernia repair. Hernia 2012;16:505-18.  Back to cited text no. 15
    
16.
Sajid MS, Kalra L, Parampalli U, Sains PS, Baig MK. A systematic review and meta-analysis evaluating the effectiveness of lightweight mesh against heavyweight mesh in influencing the incidence of chronic groin pain following laparoscopic inguinal hernia repair. Am J Surg 2013;205:726-36.  Back to cited text no. 16
    
17.
Huntington CR, Wormer BA, Cox TC, Blair LJ, Lincourt AE, Augenstein VA, et al. Local anesthesia in open inguinal hernia repair improves postoperative quality of life compared to general anesthesia: A prospective, international study. Am Surg 2015;81:704-9.  Back to cited text no. 17
    
18.
Boogaard S, Heymans MW, Patijn J, de Vet HC, Faber CG, Peters ML, et al. Predictors for persistent neuropathic pain – A delphi survey. Pain Physician 2011;14:559-68.  Back to cited text no. 18
    
19.
Boogaard S, Heymans MW, de Vet HC, Peters ML, Loer SA, Zuurmond WW, et al. Predictors of persistent neuropathic pain – A systematic review. Pain Physician 2015;18:433-57.  Back to cited text no. 19
    
20.
Wilson GC, Quillin RC 3rd, Hanseman DJ, Lewis JD, Edwards MJ, Shaughnessy EA. Incidence and predictors of neuropathic pain following breast surgery. Ann Surg Oncol 2013;20:3330-4.  Back to cited text no. 20
    
21.
Park JW, Kim HS, Yun JY, Han I. Neuropathic pain after sarcoma surgery: Prevalence and predisposing factors. Medicine (Baltimore) 2018;97:e10852.  Back to cited text no. 21
    
22.
Miserez M, Peeters E, Aufenacker T, Bouillot JL, Campanelli G, Conze J, et al. Update with level 1 studies of the European Hernia Society guidelines on the treatment of inguinal hernia in adult patients. Hernia 2014;18:151-63.  Back to cited text no. 22
    
23.
Amid PK, Hiatt JR. New understanding of the causes and surgical treatment of postherniorrhaphy inguinodynia and orchalgia. J Am Coll Surg 2007;205:381-5.  Back to cited text no. 23
    
24.
Tasmuth T, Blomqvist C, Kalso E. Chronic post-treatment symptoms in patients with breast cancer operated in different surgical units. Eur J Surg Oncol 1999;25:38-43.  Back to cited text no. 24
    
25.
Schnabel A, Pogatzki-Zahn E. Predictors of chronic pain following surgery. What do we know?. Schmerz 2010;24:517-31.  Back to cited text no. 25
    
26.
Beloeil H, Sion B, Rousseau C, Albaladejo P, Raux M, Aubrun F, et al. Early postoperative neuropathic pain assessed by the DN4 score predicts an increased risk of persistent postsurgical neuropathic pain. Eur J Anaesthesiol 2017;34:652-7.  Back to cited text no. 26
    
27.
Menorca RM, Fussell TS, Elfar JC. Nerve physiology: Mechanisms of injury and recovery. Hand Clin 2013;29:317-30.  Back to cited text no. 27
    
28.
Chhabra A, Williams EH, Wang KC, Dellon AL, Carrino JA. MR neurography of neuromas related to nerve injury and entrapment with surgical correlation. AJNR Am J Neuroradiol 2010;31:1363-8.  Back to cited text no. 28
    
29.
Demirer SD, Kepenekci I, Evirgen O, Birsen O, Tuzuner A, Karahuseyinoglu S, et al. The effect of polypropylene mesh on the ilioinguinal nerve in open mesh repair of groin hernia. In: Schumpelick V, Fitzgibbons RJ, editors. Hernia Repair Sequelae. Berlin, Heidelberg: Springer Berlin Heidelberg; 2010. p. 265-73.  Back to cited text no. 29
    
30.
Andersen HH, Duroux M, Gazerani P. MicroRNAs as modulators and biomarkers of inflammatory and neuropathic pain conditions. Neurobiol Dis 2014;71:159-68.  Back to cited text no. 30
    
31.
Basbaum AI, Bautista DM, Scherrer G, Julius D. Cellular and molecular mechanisms of pain. Cell 2009;139:267-84.  Back to cited text no. 31
    
32.
Jensen TS, Finnerup NB. Allodynia and hyperalgesia in neuropathic pain: Clinical manifestations and mechanisms. Lancet Neurol 2014;13:924-35.  Back to cited text no. 32
    
33.
Baron R, Binder A, Wasner G. Neuropathic pain: Diagnosis, pathophysiological mechanisms, and treatment. Lancet Neurol 2010;9:807-19.  Back to cited text no. 33
    
34.
Gilron I, Baron R, Jensen T. Neuropathic pain: Principles of diagnosis and treatment. Mayo Clin Proc 2015;90:532-45.  Back to cited text no. 34
    
35.
Aasvang EK, Møhl B, Bay-Nielsen M, Kehlet H. Pain related sexual dysfunction after inguinal herniorrhaphy. Pain 2006;122:258-63.  Back to cited text no. 35
    
36.
Ece İ, Yılmaz H. An overlooked complication of the inguinal hernia repair: Dysejaculation. Turk J Surg 2018;34:1-4.  Back to cited text no. 36
    
37.
Töns C, Schumpelick V. The ramus genitalis syndrome following hernia repair. A clinical study concerning its preventability. Chirurg 1990;61:441-3.  Back to cited text no. 37
    
38.
Haanpää M, Rowbothan M. Diagnosing neuropathic pain: Clinical examination, neurophysiology, and neuroimaging. In: Tracey I, editor. Pain 2012: Refresher Courses, 14th World Congress on Pain. Seattle, WA: IASP Press; 2012. p. 111-22.  Back to cited text no. 38
    
39.
Lagerburg V, Bakkers M, Bouwhuis A, Hoeijmakers JG, Smit AM, Van Den Berg SJ, et al. Contact heat evoked potentials: Normal values and use in small-fiber neuropathy. Muscle Nerve 2015;51:743-9.  Back to cited text no. 39
    
40.
Page B, Paterson C, Young D, O'Dwyer PJ. Pain from primary inguinal hernia and the effect of repair on pain. Br J Surg 2002;89:1315-8.  Back to cited text no. 40
    
41.
Smeds S, Löfström L, Eriksson O. Influence of nerve identification and the resection of nerves 'at risk' on postoperative pain in open inguinal hernia repair. Hernia 2010;14:265-70.  Back to cited text no. 41
    
42.
Bischoff JM, Aasvang EK, Kehlet H, Werner MU. Does nerve identification during open inguinal herniorrhaphy reduce the risk of nerve damage and persistent pain? Hernia 2012;16:573-7.  Back to cited text no. 42
    
43.
Amid PK. Lichtenstein tension-free hernioplasty: Its inception, evolution, and principles. Hernia 2004;8:1-7.  Back to cited text no. 43
    
44.
Amid PK. Groin hernia repair: Open techniques. World J Surg 2005;29:1046-51.  Back to cited text no. 44
    
45.
Amid PK. Causes, prevention, and surgical treatment of postherniorrhaphy neuropathic inguinodynia: Triple neurectomy with proximal end implantation. Hernia 2004;8:343-9.  Back to cited text no. 45
    
46.
Whiteside JL, Barber MD, Walters MD, Falcone T. Anatomy of ilioinguinal and iliohypogastric nerves in relation to trocar placement and low transverse incisions. Am J Obstet Gynecol 2003;189:1574-8.  Back to cited text no. 46
    
47.
Amid PK, Chen DC. Surgical treatment of chronic groin and testicular pain after laparoscopic and open preperitoneal inguinal hernia repair. J Am Coll Surg 2011;213:531-6.  Back to cited text no. 47
    
48.
Wijsmuller AR, van Veen RN, Bosch JL, Lange JF, Kleinrensink GJ, Jeekel J, et al. Nerve management during open hernia repair. Br J Surg 2007;94:17-22.  Back to cited text no. 48
    
49.
Hsu W, Chen CS, Lee HC, Liang HH, Kuo LJ, Wei PL, et al. Preservation versus division of ilioinguinal nerve on open mesh repair of inguinal hernia: A meta-analysis of randomized controlled trials. World J Surg 2012;36:2311-9.  Back to cited text no. 49
    
50.
Charalambous MP, Charalambous CP. Incidence of chronic groin pain following open mesh inguinal hernia repair, and effect of elective division of the ilioinguinal nerve: Meta-analysis of randomized controlled trials. Hernia 2018;22:401-9.  Back to cited text no. 50
    
51.
Pappalardo G, Frattaroli FM, Mongardini M, Salvi PF, Lombardi A, Conte AM, et al. Neurectomy to prevent persistent pain after inguinal herniorraphy: A prospective study using objective criteria to assess pain. World J Surg 2007;31:1081-6.  Back to cited text no. 51
    
52.
Sanders DL, Waydia S. A systematic review of randomised control trials assessing mesh fixation in open inguinal hernia repair. Hernia 2014;18:165-76.  Back to cited text no. 52
    
53.
Ismail A, Abushouk AI, Elmaraezy A, Abdelkarim AH, Shehata M, Abozaid M, et al. Self-gripping versus sutured mesh fixation methods for open inguinal hernia repair: A systematic review of clinical trials and observational studies. Surgery 2017;162:18-36.  Back to cited text no. 53
    
54.
Lin H, Zhuang Z, Ma T, Sun X, Huang X, Li Y. A meta-analysis of randomized control trials assessing mesh fixation with glue versus suture in lichtenstein inguinal hernia repair. Medicine (Baltimore) 2018;97:e0227.  Back to cited text no. 54
    
55.
Kaul A, Hutfless S, Le H, Hamed SA, Tymitz K, Nguyen H, et al. Staple versus fibrin glue fixation in laparoscopic total extraperitoneal repair of inguinal hernia: A systematic review and meta-analysis. Surg Endosc 2012;26:1269-78.  Back to cited text no. 55
    
56.
Shi Z, Fan X, Zhai S, Zhong X, Huang D. Fibrin glue versus staple for mesh fixation in laparoscopic transabdominal preperitoneal repair of inguinal hernia: A meta-analysis and systematic review. Surg Endosc 2017;31:527-37.  Back to cited text no. 56
    
57.
Reynvoet E, Berrevoet F. Pros and cons of tacking in laparoscopic hernia repair. Surg Technol Int 2014;25:136-40.  Back to cited text no. 57
    
58.
HerniaSurge Group. International guidelines for groin hernia management. Hernia 2018;22:1-65.  Back to cited text no. 58
    
59.
Bittner R, Montgomery MA, Arregui E, Bansal V, Bingener J, Bisgaard T, et al. Update of guidelines on laparoscopic (TAPP) and endoscopic (TEP) treatment of inguinal hernia (International Endohernia Society). Surg Endosc 2015;29:289-321.  Back to cited text no. 59
    
60.
Sun L, Shen YM, Chen J. Laparoscopic versus Lichtenstein hernioplasty for inguinal hernias: A systematic review and meta-analysis of randomized controlled trials. Minim Invasive Ther Allied Technol 2019. DOI: 10.1080/13645706.2019.1569534.  Back to cited text no. 60
    
61.
Bansal VK, Misra MC, Babu D, Victor J, Kumar S, Sagar R, et al. Aprospective, randomized comparison of long-term outcomes: Chronic groin pain and quality of life following totally extraperitoneal (TEP) and transabdominal preperitoneal (TAPP) laparoscopic inguinal hernia repair. Surg Endosc 2013;27:2373-82.  Back to cited text no. 61
    
62.
Iraniha A, Peloquin J. Long-term quality of life and outcomes following robotic assisted TAPP inguinal hernia repair. J Robot Surg 2018;12:261-9.  Back to cited text no. 62
    
63.
Clarke H, Bonin RP, Orser BA, Englesakis M, Wijeysundera DN, Katz J. The prevention of chronic postsurgical pain using gabapentin and pregabalin: A combined systematic review and meta-analysis. Anesth Analg 2012;115:428-42.  Back to cited text no. 63
    
64.
Dworkin RH, McDermott MP, Raja SN. Preventing chronic postsurgical pain: How much of a difference makes a difference? Anesthesiology 2010;112:516-8.  Back to cited text no. 64
    
65.
Sen H, Sizlan A, Yanarateş O, Senol MG, Inangil G, Sücüllü I, et al. The effects of gabapentin on acute and chronic pain after inguinal herniorrhaphy. Eur J Anaesthesiol 2009;26:772-6.  Back to cited text no. 65
    
66.
Ahiskalioglu EO, Ahiskalioglu A, Aydin P, Arslan Z, Aksoy M, Temiz A. Effects of a single-dose preemptive pregabalin on acute and chronic pain after inguinal hernia repair with mesh under spinal anaesthesia: A randomised controlled trial. Eur J Anaesthesiol 2016;33:605-7.  Back to cited text no. 66
    
67.
Andreae MH, Andreae DA. Regional anaesthesia to prevent chronic pain after surgery: A Cochrane systematic review and meta-analysis. Br J Anaesth 2013;111:711-20.  Back to cited text no. 67
    
68.
Turk DC, Wilson HD. Fear of pain as a prognostic factor in chronic pain: Conceptual models, assessment, and treatment implications. Curr Pain Headache Rep 2010;14:88-95.  Back to cited text no. 68
    
69.
Alfieri S, Rotondi F, Di Giorgio A, Fumagalli U, Salzano A, Di Miceli D, et al. Influence of preservation versus division of ilioinguinal, iliohypogastric, and genital nerves during open mesh herniorrhaphy: Prospective multicentric study of chronic pain. Ann Surg 2006;243:553-8.  Back to cited text no. 69
    
70.
Aasvang E, Kehlet H. Surgical management of chronic pain after inguinal hernia repair. Br J Surg 2005;92:795-801.  Back to cited text no. 70
    
71.
Aasvang EK, Kehlet H. The effect of mesh removal and selective neurectomy on persistent postherniotomy pain. Ann Surg 2009;249:327-34.  Back to cited text no. 71
    
72.
Loos MJ, Scheltinga MR, Roumen RM. Tailored neurectomy for treatment of postherniorrhaphy inguinal neuralgia. Surgery 2010;147:275-81.  Back to cited text no. 72
    
73.
Amid PK. A 1-stage surgical treatment for postherniorrhaphy neuropathic pain: Triple neurectomy and proximal end implantation without mobilization of the cord. Arch Surg 2002;137:100-4.  Back to cited text no. 73
    
74.
Giger U, Wente MN, Büchler MW, Krähenbühl S, Lerut J, Krähenbühl L, et al. Endoscopic retroperitoneal neurectomy for chronic pain after groin surgery. Br J Surg 2009;96:1076-81.  Back to cited text no. 74
    
75.
Chen DC, Hiatt JR, Amid PK. Operative management of refractory neuropathic inguinodynia by a laparoscopic retroperitoneal approach. JAMA Surg 2013;148:962-7.  Back to cited text no. 75
    
76.
Wong J, Anvari M. Treatment of inguinodynia after laparoscopic herniorrhaphy: A combined laparoscopic and fluoroscopic approach to the removal of helical tackers. Surg Laparosc Endosc Percutan Tech 2001;11:148-51.  Back to cited text no. 76
    
77.
Bischoff JM, Koscielniak-Nielsen ZJ, Kehlet H, Werner MU. Ultrasound-guided ilioinguinal/iliohypogastric nerve blocks for persistent inguinal postherniorrhaphy pain: A randomized, double-blind, placebo-controlled, crossover trial. Anesth Analg 2012;114:1323-9.  Back to cited text no. 77
    
78.
Thomassen I, van Suijlekom JA, van de Gaag A, Ponten JE, Nienhuijs SW. Ultrasound-guided ilioinguinal/iliohypogastric nerve blocks for chronic pain after inguinal hernia repair. Hernia 2013;17:329-32.  Back to cited text no. 78
    
79.
Fanelli RD, DiSiena MR, Lui FY, Gersin KS. Cryoanalgesic ablation for the treatment of chronic postherniorrhaphy neuropathic pain. Surg Endosc 2003;17:196-200.  Back to cited text no. 79
    
80.
Werner MU, Bischoff JM, Rathmell JP, Kehlet H. Pulsed radiofrequency in the treatment of persistent pain after inguinal herniotomy: A systematic review. Reg Anesth Pain Med 2012;37:340-3.  Back to cited text no. 80
    
81.
Makharita MY, Amr YM. Pulsed radiofrequency for chronic inguinal neuralgia. Pain Physician 2015;18:E147-55.  Back to cited text no. 81
    
82.
Banh DP, Moujan PM, Haque Q, Han TH. Permanent implantation of peripheral nerve stimulator for combat injury-related ilioinguinal neuralgia. Pain Physician 2013;16:E789-91.  Back to cited text no. 82
    
83.
Yakovlev AE, Al Tamimi M, Barolat G, Karasev SA, Merkulov YA, Resch BE, et al. Spinal cord stimulation as alternative treatment for chronic post-herniorrhaphy pain. Neuromodulation 2010;13:288-90.  Back to cited text no. 83
    


    Figures

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