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Metastatic lung neuroendocrine carcinoma presenting as a breast lump

1 Department of General Surgery, Kuo General Hospital, Tainan, Taiwan
2 Department of Pathology, Kuo General Hospital, Tainan, Taiwan
3 Department of Internal Medicine, Kuo General Hospital, Tainan, Taiwan

Correspondence Address:
Yu-Lin Chang,
Department of Internal Medicine, Tainan Kuo General Hospital, No. 22, Sec. 2, Minsheng Rd., West Central Dist., Tainan City 700
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/fjs.fjs_55_18

This case is a 78-year-old woman with hypertension, diabetes mellitus, cardiovascular disease, valvular heart failure and hepatitis C. She presented to outpatient department for her right breast lump. The pathology of the core biopsy under breast sonography showed carcinoma with neuroendocrine features. Its immunohistochemical study showed negative for estrogen receptor (ER), progesterone Receptor (PR), HER2/neu and GATA-3, and positive for chromogranin A, synaptophysin, and TTF-1. A staging workup was then performed. The computed tomography (CT) of chest and abdomen revealed another mass in the left lung. CT-guided biopsy was done for the lung mass. According to the results of immunostains, a primary lung large cell neuroendocrine carcinoma (LCNEC) with breast metastasis was diagnosed. The patient received chemotherapy with etoposide and carboplatin for 6 cycles. The CT performed 3 and 5 months later showed that the response of the tumors was stable.

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