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Procalcitonin levels to predict bacterial infection in Surgical Intensive Care Unit patients
Jin You Jhan1, Yen Ta Huang2, Cian Huei Shih3, Jhen Da Yang4, Yi Tsen Lin5, Shin-Jie Lin5, Hsiao Hui Yang6, Lee Ying Soo7, Guan Jin Ho8
1 Department of Surgery, Buddhist Tzu Chi General Hospital; Division of Cardiothoracic Surgery, Buddhist Tzu Chi General Hospital, Hualien, Taiwan
2 Department of Surgery; Surgical Intensive Care Unit, Buddhist Tzu Chi General Hospital; Department of Pharmacology, Tzu Chi University, Hualien, Taiwan
3 Nurse Practitioner, Department of Nursing, Surgical Intensive Care Unit, Buddhist Tzu Chi General Hospital; Ph.D. Student, Institute of Medical Sciences, Tzu Chi University, Hualien, Taiwan
4 Nurse Practitioner, Department of Nursing, Surgical Intensive Care Unit, Buddhist Tzu Chi General Hospital, Hualien, Taiwan
5 Nurse Practitioner, Department of Nursing, Surgical Intensive Care Unit, Buddhist Tzu Chi General Hospital; M.S. Student, Institute of Nursing, Tzu Chi University, Hualien, Taiwan
6 Department of Surgery, Buddhist Tzu Chi General Hospital; School of Medicine, Tzu Chi University, Hualien, Taiwan
7 Department of Surgical Intensive Care Unit, Buddhist Tzu Chi General Hospital, Hualien, Taiwan
8 Department of Surgical Intensive Care Unit, Buddhist Tzu Chi General Hospital; School of Medicine, Tzu Chi University, Hualien, Taiwan
Correspondence Address:
Guan Jin Ho
SICU of Tzu Chi General Hospital, 707, Section 3, Chung Yang Road, Hualien 970
Taiwan
 Source of Support: None, Conflict of Interest: None
DOI: 10.4103/fjs.fjs_54_17
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Background: Infection-induced inflammatory response might be aggravated by surgery insults. The clinical presentation of Surgical Intensive Care Unit (SICU) patients might be different from medical critically ill patients.
Purpose: To evaluate the diagnostic and prognostic values of procalcitonin (PCT) to predict bacterial infection in SICU patients.
Methods: We retrospectively analyzed the 2-year (2013 and 2014) records of 342 adult SICU cases with suspected bacterial infection in SICU of Hualien Tzu Chi Hospital. The past histories, the first infection-related parameters when SICU admission, culture results, infection-related laboratory examinations, and outcomes were collected.
Results: Median of PCT level in patients with negative and any positive culture was 0.84 (interquartile range [IQR] 0.18–6.21) and 2.27 (IQR 0.54–9.93) ng/ml, respectively. Infection from blood, urine, and skin/soft tissue elicited significantly higher PCT levels. PCT in receiver operating characteristic (ROC) curve demonstrated the most accurate to predict bacterial infection (area under the ROC curve [AUC]: 0.61; 95% confidence interval [CI]: 0.54–0.63) and bacteremia (AUC: 0.73; 95% CI: 0.66–0.80) compared to white blood cell count, ratio of neutrophils, and neutrophil-to-lymphocyte count ratio (NLCR). Significantly higher PCT levels (4.12 ng/ml, 1.12–19.99; median, IQR) were observed in mortality cases. Higher PCT levels were significantly accompanied with higher NLCR, as well as higher incidence of leukopenia and bandemia. Using Kaplan–Meier analysis, significantly higher intrahospital mortality was observed in cases with above the cutoff PCT levels of 0.5 and 2 ng/ml cases, respectively.
Conclusion: PCT is a relatively more useful tool to predict bacterial and particularly bloodstream infection compared to other infection-related parameters in routinely clinical practice. Initial PCT levels may be a prognostic factor of SICU patients with bacterial infection. |
