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Year : 2022  |  Volume : 55  |  Issue : 4  |  Page : 158-160

Cerebral venous sinus thrombosis-associated hemorrhage in vaccine-induced immune thrombotic thrombocytopenia: Catastrophic outcome if delayed diagnosis and treatment

1 Department of Neurosurgery, Shin Kong Wu Ho-Su Memorial Hospital, New Taipei, Taiwan
2 Department of Neurology, Shin Kong Wu Ho-Su Memorial Hospital, New Taipei, Taiwan
3 Department of Neurosurgery, Shin Kong Wu Ho-Su Memorial Hospital; School of Medicine, College of Medicine, Fu Jen Catholic University, New Taipei, Taiwan

Correspondence Address:
Ming-Cheng Tsai
No. 95, Wenchang RD, Shilin Dist., Taipei City
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/fjs.fjs_236_21

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The authors reported the clinical course of a 58-year-old female suffering from cerebral venous sinus thrombosis associated with hemorrhage after the ChAdOx1 nCov-19 vaccination. Emergent decompressive craniectomy was performed, and aggressive blood transfusion was given. Nevertheless, progressive intracerebral hemorrhage and thrombocytopenia developed. A delayed diagnosis was made on a rare complication of vaccine-induced immune thrombotic thrombocytopenia (VITT) with a positive result of anti-platelet factor 4 antibodies (PF4 Ab). The patient died 4 days postoperative due to brainstem failure.

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